RN 1734

• Supplier: Tocris Bioscience
• Catalog: 4977
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 946387-07-1
• Chemical Name: 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide
• Formula: C14H22Cl2N2O2S
• Molecular Weight: 353.31
• Description: Selective TRPV4 antagonist (IC 50 values are 2.3, 3.2 and 5.9 μ M for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.

Product References

Identification and characterization of novel TRPV4 modulators. - Identification and characterization of novel TRPV4 modulators.

Vincent F, Acevedo A, Nguyen MT, Dourado M, DeFalco J, Gustafson A, Spiro P, Emerling DE, Kelly MG, Duncton MA. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4. doi:

Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ - Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+

Bagher P, Beleznai T, Kansui Y, Mitchell R, Garland CJ, Dora KA. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18174-9. doi: