RN 9893 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3745
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1803003-68-0
• Chemical Name: N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamidehydrochloride
• Formula: C21H23F3N4O5S.HCl
• Molecular Weight: 536.95
• Purity: >99 %
• Description: Potent and selective TRPV4 antagonist (IC 50 values are 320, 420 and 660 nM for mouse, human and rat channels, respectively). Exhibits >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. Orally bioavailable.

Product References

Positive allosteric modulators of metabotropic glutamate 1 receptor: - Positive allosteric modulators of metabotropic glutamate 1 receptor:

Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7. Epub 2001 Oct 23.

A novel class of positive allosteric modulators of metabotropic glutamate - A novel class of positive allosteric modulators of metabotropic glutamate

Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ. Mol Pharmacol. 2006 Aug;70(2):616-26. Epub 2006 Apr 27.

Activation of a dimeric metabotropic glutamate receptor by intersubunit - Activation of a dimeric metabotropic glutamate receptor by intersubunit

Brock C, Oueslati N, Soler S, Boudier L, Rondard P, Pin JP. J Biol Chem. 2007 Nov 9;282(45):33000-8. Epub 2007 Sep 13.