Ro 0437626

Name Ro 0437626
Supplier Tocris Bioscience
Catalog 4348
Prices $139.00, $299.00
Sizes 1 mg, 10 mg
Function Type Antagonist
Cas Number 134362-79-1
Chemical Name N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide
Formula C27H35N5O4S
Molecular Weight 525.66
Purity >98 %
Description Selective P2X 1 purinergic receptor antagonist (IC 50 = 3 μ M) that displays > 30-fold selectivity over P2X 2 , P2X 3 and P2X 2/3 receptors (IC 50 > 100 μ M).
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Product References

Investigation of the effects of P2 purinoceptor ligands on the micturition reflex - Investigation of the effects of P2 purinoceptor ligands on the micturition reflex

King BF, Knowles ID, Burnstock G, Ramage AG. Br J Pharmacol. 2004 Jun;142(3):519-30. Epub 2004 May 17.

Discovery and synthesis of a novel and selective drug-like P2X(1) antagonist. - Discovery and synthesis of a novel and selective drug-like P2X(1) antagonist.

Jaime-Figueroa S, Greenhouse R, Padilla F, Dillon MP, Gever JR, Ford AP. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3292-5.

Purinoceptors as therapeutic targets for lower urinary tract dysfunction. - Purinoceptors as therapeutic targets for lower urinary tract dysfunction.

Ford AP, Gever JR, Nunn PA, Zhong Y, Cefalu JS, Dillon MP, Cockayne DA. Br J Pharmacol. 2006 Feb;147 Suppl 2:S132-43.