Ro 04-6790

• Supplier: Tocris Bioscience
• Catalog: 2005
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 202466-68-0
• Chemical Name: 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide
• Formula: C12H16N6O2S
• Molecular Weight: 308.36
• Purity: >98 %
• Description: Potent and selective 5-HT 6 receptor antagonist (pK i values are 7.26 and 7.35 at rat and human 5-HT 6 receptors respectively). Displays no affinity at a range of other receptors (IC 50 > 10 μ M). Induces stretching behavior in rats in vivo .

Product References

Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists - Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists

Sleight AJ, Boess FG, Bos M, Levet-Trafit B, Riemer C, Bourson A. Br J Pharmacol. 1998 Jun;124(3):556-62.

Investigation of stretching behaviour induced by the selective 5-HT6 receptor - Investigation of stretching behaviour induced by the selective 5-HT6 receptor

Bentley JC, Bourson A, Boess FG, Fone KC, Marsden CA, Petit N, Sleight AJ. Br J Pharmacol. 1999 Apr;126(7):1537-42.

An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. - An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function.

Fone KC. Neuropharmacology. 2008 Nov;55(6):1015-22.