| Name | Ro 106-9920 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2329 |
| Prices | $139.00, $585.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 62645-28-7 |
| Chemical Name | 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine |
| Formula | C10H7N5OS |
| Molecular Weight | 245.26 |
| Purity | >99 % |
| Description | Inhibitor of NF- κ B activation, possibly via selective inhibition of LPS- and TNF- α -induced I κ B α ubiquitination (IC 50 = 3 μ M). Blocks subsequent production of TNF- α , IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo . Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. |
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Swinney DC, Xu YZ, Scarafia LE, Lee I, Mak AY, Gan QF, Ramesha CS, Mulkins MA, Dunn J, So OY, Biegel T, Dinh M, Volkel P, Barnett J, Dalrymple SA, Lee S, Huber M. J Biol Chem. 2002 Jun 28;277(26):23573-81. Epub 2002 Apr 11.