Ro 1138452 hydrochloride

Name Ro 1138452 hydrochloride
Supplier Tocris Bioscience
Catalog 1778
Prices $195.00, $805.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Chemical Name 4,5-Dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imidazol-2-aminehydrochloride
Formula C19H23N3O.HCl
Molecular Weight 345.87
Purity >98 %
Description Selective prostacyclin IP receptor antagonist (pK i = 8.3). Exhibits no affinity at other prostanoid receptors (EP 1-4 , FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailable.
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Product References

Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin - Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin

Clark RD, Jahangir A, Severance D, Salazar R, Chang T, Chang D, Jett MF, Smith S, Bley K. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1053-6.

RO1138452 and RO3244794: characterization of structurally distinct, potent and - RO1138452 and RO3244794: characterization of structurally distinct, potent and

Bley KR, Bhattacharya A, Daniels DV, Gever J, Jahangir A, O'Yang C, Smith S, Srinivasan D, Ford AP, Jett MF. Br J Pharmacol. 2006 Feb;147(3):335-45.

Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated - Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated

Jones RL, Wise H, Clark R, Whiting RL, Bley KR. Br J Pharmacol. 2006 Sep;149(1):110-20. Epub 2006 Jul 31.