Ro 19-4603

• Supplier: Tocris Bioscience
• Catalog: 1997
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 99632-94-7
• Chemical Name: 5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylicacid1,1-dimethylethylester
• Formula: C15H17N3O3S
• Molecular Weight: 319.38
• Purity: >99 %
• Description: Benzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABA A receptors (K i values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.

Product References

High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors. - High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors.

Wong G, Skolnick P. Eur J Pharmacol. 1992 Jan 14;225(1):63-8.

Effects of the benzodiazepine inverse agonist RO19-4603 on the maintenance of - Effects of the benzodiazepine inverse agonist RO19-4603 on the maintenance of

June HL, Duemler SE, Greene TL, Williams JA, Lin M, Devaraju SL, Chen SH, Lewis MJ, Murphy JM. J Pharmacol Exp Ther. 1995 Sep;274(3):1105-12.

The novel benzodiazepine inverse agonist RO19-4603 antagonizes ethanol motivated - The novel benzodiazepine inverse agonist RO19-4603 antagonizes ethanol motivated

June HL, Torres L, Cason CR, Hwang BH, Braun MR, Murphy JM. Brain Res. 1998 Feb 16;784(1-2):256-75.