Ro 20-1724

• Supplier: Tocris Bioscience
• Catalog: 1995
• Prices: $75.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 29925-17-5
• Chemical Name: 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone
• Formula: C15H22N2O3
• Molecular Weight: 278.35
• Purity: >99 %
• Description: Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

Product References

The identification of a new cyclic nucleotide phosphodiesterase activity in human - The identification of a new cyclic nucleotide phosphodiesterase activity in human

Reeves ML, Leigh BK, England PJ. Biochem J. 1987 Jan 15;241(2):535-41.

Differential modulation of tissue function and therapeutic potential of selective - Differential modulation of tissue function and therapeutic potential of selective

Nicholson CD, Challiss RA, Shahid M. Trends Pharmacol Sci. 1991 Jan;12(1):19-27.

Cloning and characterization of a cAMP-specific cyclic nucleotide - Cloning and characterization of a cAMP-specific cyclic nucleotide

Soderling SH, Bayuga SJ, Beavo JA. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8991-6.