Ro 25-6981 maleate

• Supplier: Tocris Bioscience
• Catalog: 0415
• Prices: $79.00, $169.00, $705.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 1312991-76-6
• Chemical Name: (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanolmaleate
• Formula: C22H29NO2.C4H4O4
• Molecular Weight: 455.55
• Purity: >98 %
• Description: Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC 50 values are 0.009 and 52 μ M for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo and in vitro .

Product References

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate - Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate

Fischer G, Mutel V, Trube G, Malherbe P, Kew JN, Mohacsi E, Heitz MP, Kemp JA. J Pharmacol Exp Ther. 1997 Dec;283(3):1285-92.

Pharmacological characterization of interactions of RO 25-6981 with the NR2B - Pharmacological characterization of interactions of RO 25-6981 with the NR2B

Lynch DR, Shim SS, Seifert KM, Kurapathi S, Mutel V, Gallagher MJ, Guttmann RP. Eur J Pharmacol. 2001 Mar 30;416(3):185-95.

The NR2B-selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 - The NR2B-selective N-methyl-D-aspartate receptor antagonist Ro 25-6981

Kosowski AR, Liljequist S. J Pharmacol Exp Ther. 2004 Nov;311(2):560-7. Epub 2004 Jul 15.