Ro 31-8220 mesylate

Name Ro 31-8220 mesylate
Supplier Tocris Bioscience
Catalog 1794
Prices $235.00
Sizes 10 mg
Function Type Inhibitor
Cas Number 138489-18-6
Chemical Name 3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propylcarbamimidothioicacidestermesylate
Formula C25H23N5O2S.CH3SO3H
Molecular Weight 553.65
Purity >97 %
Description Protein kinase C inhibitor, with activity at other protein kinases (IC 50 values are 33, 3, 8, 15 and 38 nM for PKC α , MAPKAP-K1b, MSK1, GSK3 β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na + channels in the micromolar range.
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Product References

Potent selective inhibitors of protein kinase C. - Potent selective inhibitors of protein kinase C.

Davis PD, Hill CH, Keech E, Lawton G, Nixon JS, Sedgwick AD, Wadsworth J, Westmacott D, Wilkinson SE. FEBS Lett. 1989 Dec 18;259(1):61-3.

Specificity and mechanism of action of some commonly used protein kinase - Specificity and mechanism of action of some commonly used protein kinase

Davies SP, Reddy H, Caivano M, Cohen P. Biochem J. 2000 Oct 1;351(Pt 1):95-105.

Inhibition of voltage-dependent sodium channels by Ro 31-8220, a 'specific' - Inhibition of voltage-dependent sodium channels by Ro 31-8220, a 'specific'

Lingameneni R, Vysotskaya TN, Duch DS, Hemmings HC Jr. FEBS Lett. 2000 May 12;473(2):265-8.