Ro 32-0432 hydrochloride

Name Ro 32-0432 hydrochloride
Supplier Tocris Bioscience
Catalog 2002
Prices $199.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 151342-35-7
Chemical Name 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride
Formula C28H28N4O2.HCl
Molecular Weight 489.01
Purity >99 %
Description Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca 2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α , β Ι, β ΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo .
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Product References

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein - Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein

Wilkinson SE, Parker PJ, Nixon JS. Biochem J. 1993 Sep 1;294 ( Pt 2):335-7.

Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents - Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents

Birchall AM, Bishop J, Bradshaw D, Cline A, Coffey J, Elliott LH, Gibson VM, Greenham A, Hallam TJ, Harris W, et al.. J Pharmacol Exp Ther. 1994 Feb;268(2):922-9.