Ro 3280

• Supplier: Tocris Bioscience
• Catalog: 2916
• Prices: $225.00, $945.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1062243-51-9
• Chemical Name: 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
• Formula: C27H35F2N7O3
• Molecular Weight: 543.61
• Purity: >98 %
• Description: Potent and selective PLK inhibitor (IC 50 = 3 nM). Exhibits selectivity for PLK1 over a panel of other kinases. Inhibits growth of a range of tumor cells lines in vitro and induces apoptosis in leukemia cells. Exhibits antitumor activity in mouse colorectal and nasopharyngeal cancer models in vivo .

Product References

Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation - Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation

Kojima K, Shimanuki M, Shikami M, Andreeff M, Nakakuma H. Cancer Sci. 2009 Jun;100(6):1128-36.

CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage. - CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage.

Yu B, Dalton WB, Yang VW. Cancer Res. 2012 Nov 1;72(21):5448-53.