Ro 48-8071 fumarate

• Supplier: Tocris Bioscience
• Catalog: 4181
• Prices: $85.00, $359.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 189197-69-1
• Chemical Name: (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone
• Formula: C23H27BrFNO2.C4H4O4
• Molecular Weight: 564.44
• Purity: >99 %
• Description: 2,3-Oxidosqualene cyclase (OSC) inhibitor (IC 50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC 50 = 1.74 μ M).

Product References

Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma - Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma

Morand OH, Aebi JD, Dehmlow H, Ji YH, Gains N, Lengsfeld H, Himber J. J Lipid Res. 1997 Feb;38(2):373-90.

An inverse docking approach for identifying new potential anti-cancer targets. - An inverse docking approach for identifying new potential anti-cancer targets.

Grinter SZ, Liang Y, Huang SY, Hyder SM, Zou X. J Mol Graph Model. 2011 Apr;29(6):795-9.

Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola - Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola

Shoemaker CJ, Schornberg KL, Delos SE, Scully C, Pajouhesh H, Olinger GG, Johansen LM, White JM. PLoS One. 2013;8(2):e56265.