Ro 60-0175 fumarate

Name	Ro 60-0175 fumarate
Supplier	Tocris Bioscience
Catalog	4694
Prices	$139.00, $585.00
Sizes	10 mg, 50 mg
Function Type	Agonist
Cas Number	169675-09-6
Chemical Name	(αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanaminefumarate
Formula	C11H12ClFN2.C4H4O4
Molecular Weight	342.75
Purity	>98 %
Description	Potent, selective 5-HT 2 receptor agonist; shows selectivity for the 5-HT 2C subtype (pK i values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT 2C , 2A , 1A , 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo .
Supplier Page	Shop

Product References

5-HT2C receptor agonists: pharmacological characteristics and therapeutic - 5-HT2C receptor agonists: pharmacological characteristics and therapeutic

Martin JR, Bos M, Jenck F, Moreau J, Mutel V, Sleight AJ, Wichmann J, Andrews JS, Berendsen HH, Broekkamp CL, Ruigt GS, Kohler C, Delft AM. J Pharmacol Exp Ther. 1998 Aug;286(2):913-24.

Effects of RO 60 0175, a 5-HT(2C) receptor agonist, in three animal models of - Effects of RO 60 0175, a 5-HT(2C) receptor agonist, in three animal models of

Kennett G, Lightowler S, Trail B, Bright F, Bromidge S. Eur J Pharmacol. 2000 Jan 10;387(2):197-204.

Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol- - Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol-

Damjanoska KJ, Muma NA, Zhang Y, D'Souza DN, Garcia F, Carrasco GA, Kindel GH, Haskins KA, Shankaran M, Petersen BR, Van De Kar LD. J Pharmacol Exp Ther. 2003 Mar;304(3):1209-16.

Design, synthesis, and pharmacological characterization of N- and O-substituted - Design, synthesis, and pharmacological characterization of N- and O-substituted

Jensen AA, Plath N, Pedersen MH, Isberg V, Krall J, Wellendorph P, Stensbol TB, Gloriam DE, Krogsgaard-Larsen P, Frolund B. J Med Chem. 2013 Feb 14;56(3):1211-27.