Ro 67-4853

• Supplier: Tocris Bioscience
• Catalog: 2913
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 302841-89-0
• Chemical Name: (9H-Xanthen-9-ylcarbonyl)-carbamicacidbutylester
• Formula: C19H19NO4
• Molecular Weight: 325.36
• Purity: >99 %
• Description: Positive allosteric modulator of mGlu group I receptors (pEC 50 value is 7.16 for the rat mGlu 1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu 1 and rat mGlu 5 . Enhances the effects of ( S )-DHPG in CA3 neurons (EC 50 = 95 nM).

Product References

Positive allosteric modulators of metabotropic glutamate 1 receptor: - Positive allosteric modulators of metabotropic glutamate 1 receptor:

Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7. Epub 2001 Oct 23.

A novel class of positive allosteric modulators of metabotropic glutamate - A novel class of positive allosteric modulators of metabotropic glutamate

Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ. Mol Pharmacol. 2006 Aug;70(2):616-26. Epub 2006 Apr 27.