Ro 67-7476

• Supplier: Tocris Bioscience
• Catalog: 4347
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 298690-60-5
• Chemical Name: (2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
• Formula: C17H18FNO2S
• Molecular Weight: 319.39
• Purity: >99 %
• Description: Positive allosteric modulator of mGlu 1 receptors. Potentiates glutamate-induced calcium release (EC 50 = 60.1 nM at rat mGluR1a). Displays no activity at human mGlu 1 receptors.

Product References

Positive allosteric modulators of metabotropic glutamate 1 receptor: - Positive allosteric modulators of metabotropic glutamate 1 receptor:

Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7. Epub 2001 Oct 23.

A novel class of positive allosteric modulators of metabotropic glutamate - A novel class of positive allosteric modulators of metabotropic glutamate

Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ. Mol Pharmacol. 2006 Aug;70(2):616-26. Epub 2006 Apr 27.