| Name | Ro 6842262 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4346 |
| Prices | $205.00, $865.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 1396006-71-5 |
| Chemical Name | 1-[4'-[4-Methyl-5-[[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1'-biphenyl]-4-yl]cyclopropanecarboxylicacid |
| Formula | C28H26N4O4 |
| Molecular Weight | 482.53 |
| Purity | >98 % |
| Description | Potent LPA 1 antagonist (IC 50 = 25 nM). Exhibits >1,200-fold selectivity for LPA 1 over LPA 3 . Attenuates NHLF human lung fibroblast cell proliferation and contraction in vitro . Also reduces plasma histamine levels in mouse LPA-challenge model. Orally bioavailable. |
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Kew JN, Trube G, Kemp JA. Br J Pharmacol. 1998 Feb;123(3):463-72.
Kew JN, Kemp JA. J Physiol. 1998 Oct 1;512 ( Pt 1):17-28.