| Name | RO-3 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2408 |
| Prices | $159.00 |
| Sizes | 10 mg |
| Function Type | Antagonist |
| Cas Number | 1026582-88-6 |
| Chemical Name | 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine |
| Formula | C16H22N4O2 |
| Molecular Weight | 302.37 |
| Purity | >98 % |
| Description | Selective homomeric P2X 3 and heteromeric P2X 2/3 receptor antagonist (pIC 50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X 1 , P2X 2 , P2X 4 , P2X 5 and P2X 7 receptors (IC 50 > 10 μ M). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant. |
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Ford AP, Gever JR, Nunn PA, Zhong Y, Cefalu JS, Dillon MP, Cockayne DA. Br J Pharmacol. 2006 Feb;147 Suppl 2:S132-43.
Donnelly-Roberts D, McGaraughty S, Shieh CC, Honore P, Jarvis MF. J Pharmacol Exp Ther. 2008 Feb;324(2):409-15. Epub 2007 Nov 27.