Rolipram

• Supplier: Tocris Bioscience
• Catalog: 3052
• Prices: $109.00, $459.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 61413-54-5
• Chemical Name: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
• Formula: C16H21NO3
• Molecular Weight: 275.35
• Purity: >98 %
• Description: Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC 50 = 2.0 μ M). Discriminates between two conformational states of PDE4 isoenzymes. Separate isomers ( R )-(-)-Rolipram and ( S )-(+)-Rolipram are available (Cat. Nos. 1349 and 1350 respectively).

Product References

Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine - Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine

O'Donnell JM. J Pharmacol Exp Ther. 1993 Mar;264(3):1168-78.

Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal - Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal

Kato H, Araki T, Itoyama Y, Kogure K. Eur J Pharmacol. 1995 Jan 5;272(1):107-10.

Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future? - Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?

Teixeira MM, Gristwood RW, Cooper N, Hellewell PG. Trends Pharmacol Sci. 1997 May;18(5):164-71.