( R )-(-)-Rolipram

• Supplier: Tocris Bioscience
• Catalog: 0905
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 85416-75-7
• Chemical Name: (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
• Formula: C16H21NO3
• Molecular Weight: 275.35
• Purity: >98 %
• Description: More active enantiomer of the PDE4 inhibitor rolipram (Cat. No. 0905); 2-10-fold more potent than the S-(+) enantiomer (Cat. No. 1350). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

Product References

Stereospecific binding of the antidepressant rolipram to brain protein - Stereospecific binding of the antidepressant rolipram to brain protein

Schneider HH, Schmiechen R, Brezinski M, Seidler J. Eur J Pharmacol. 1986 Aug 7;127(1-2):105-15.

Human phosphodiesterase 4A: characterization of full-length and truncated enzymes - Human phosphodiesterase 4A: characterization of full-length and truncated enzymes

Owens RJ, Catterall C, Batty D, Jappy J, Russell A, Smith B, O'Connell J, Perry MJ. Biochem J. 1997 Aug 15;326 ( Pt 1):53-60.

Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat - Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat

Ohsawa F, Yamauchi M, Nagaso H, Murakami S, Baba J, Sawa A. Jpn J Pharmacol. 1998 Jun;77(2):147-54.