Rotenone

• Supplier: Tocris Bioscience
• Catalog: 5315
• Prices: $59.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 83-79-4
• Chemical Name: (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
• Formula: C23H22O6
• Molecular Weight: 394.42
• Purity: >95 %
• Description: Mitochondrial electron transport chain inhibitor (IC 50 = 1.7 - 2.2 μ M at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC 50 = 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.

Product References

NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates - NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates

Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN. Circ Res. 2004 Mar 5;94(4):478-86. Epub 2003 Dec 29.

Neurotoxicant-induced animal models of Parkinson's disease: understanding the - Neurotoxicant-induced animal models of Parkinson's disease: understanding the

Uversky VN. Cell Tissue Res. 2004 Oct;318(1):225-41. Epub 2004 Jul 16.

Pesticides and impairment of mitochondrial function in relation with the - Pesticides and impairment of mitochondrial function in relation with the

Gomez C, Bandez MJ, Navarro A. Front Biosci. 2007 Jan 1;12:1079-93.

Rotenone inhibits autophagic flux prior to inducing cell death. - Rotenone inhibits autophagic flux prior to inducing cell death.

Mader BJ, Pivtoraiko VN, Flippo HM, Klocke BJ, Roth KA, Mangieri LR, Shacka JJ. ACS Chem Neurosci. 2012 Dec 19;3(12):1063-72.