Rottlerin

Name Rottlerin
Supplier Tocris Bioscience
Catalog 3896
Prices $89.00, $375.00
Sizes 10 mg, 50 mg
Cas Number 82-08-6
Chemical Name 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Formula C30H28O8
Molecular Weight 516.55
Description Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC 50 values are 1.9 and 5 μ M respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.
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Product References

Rottlerin, a novel protein kinase inhibitor. - Rottlerin, a novel protein kinase inhibitor.

Gschwendt M, Muller HJ, Kielbassa K, Zang R, Kittstein W, Rincke G, Marks F. Biochem Biophys Res Commun. 1994 Feb 28;199(1):93-8.

Specificity and mechanism of action of some commonly used protein kinase - Specificity and mechanism of action of some commonly used protein kinase

Davies SP, Reddy H, Caivano M, Cohen P. Biochem J. 2000 Oct 1;351(Pt 1):95-105.

Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell - Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell

Zhang D, Anantharam V, Kanthasamy A, Kanthasamy AG. J Pharmacol Exp Ther. 2007 Sep;322(3):913-22. Epub 2007 Jun 12.

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors - Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors

Balgi AD, Fonseca BD, Donohue E, Tsang TC, Lajoie P, Proud CG, Nabi IR, Roberge M. PLoS One. 2009 Sep 22;4(9):e7124.