Roxindole hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1610
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 108050-82-4
• Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-olhydrochloride
• Formula: C23H26N2O.HCl
• Molecular Weight: 382.93
• Purity: >98 %
• Description: Dopamine D 2 autoreceptor agonist, with affinity for D 3 , D 4 and 5-HT 1 receptors (pK i values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D 2 , D 3 , D 4 , 5-HT 1A , 5-HT 1B and 5-HT 1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo .

Product References

Biochemical and functional studies on EMD 49,980: a potent, selectively - Biochemical and functional studies on EMD 49,980: a potent, selectively

Seyfried CA, Greiner HE, Haase AF. Eur J Pharmacol. 1989 Jan 24;160(1):31-41.

Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. - Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist.

Bartoszyk GD, Harting J, Minck KO. J Pharmacol Exp Ther. 1996 Jan;276(1):41-8.

Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin - Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin

Newman-Tancredi A, Cussac D, Audinot V, Millan MJ. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jun;359(6):447-53.