RP 67580

• Supplier: Tocris Bioscience
• Catalog: 4289
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 135911-02-3
• Chemical Name: (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol
• Formula: C29H30N2O2
• Molecular Weight: 438.57
• Purity: >97 %
• Description: Potent and selective tachykinin NK 1 receptor antagonist (K i values are 2.9 nM and > 10 μ M for rat NK 1 , and rat NK 2 and NK 3 receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo , possibly partly via inhibition of calcium channels.

Product References

Pharmacological properties of a potent and selective nonpeptide substance P - Pharmacological properties of a potent and selective nonpeptide substance P

Garret C, Carruette A, Fardin V, Moussaoui S, Peyronel JF, Blanchard JC, Laduron PM. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10208-12.

Molecular basis for the species selectivity of the neurokinin-1 receptor - Molecular basis for the species selectivity of the neurokinin-1 receptor

Fong TM, Yu H, Strader CD. J Biol Chem. 1992 Dec 25;267(36):25668-71.

Higher potency of RP 67580, in the mouse and the rat compared with other - Higher potency of RP 67580, in the mouse and the rat compared with other

Beaujouan JC, Heuillet E, Petitet F, Saffroy M, Torrens Y, Glowinski J. Br J Pharmacol. 1993 Mar;108(3):793-800.

Antinociceptive activity of NK1 receptor antagonists: non-specific effects of - Antinociceptive activity of NK1 receptor antagonists: non-specific effects of

Rupniak NM, Boyce S, Williams AR, Cook G, Longmore J, Seabrook GR, Caeser M, Iversen SD, Hill RG. Br J Pharmacol. 1993 Dec;110(4):1607-13.