RS 102221 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1325
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 187397-18-8
• Chemical Name: 8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dionehydrochloride
• Formula: C27H31F3N4O7S.HCl
• Molecular Weight: 649.08
• Purity: >98 %
• Description: Potent and selective 5-HT 2C antagonist (pK i = 8.7). Displays ~ 100-fold selectivity over the 5-HT 2A and 5-HT 2B subtypes and is > 100-fold selective over other 5-HT receptors, α - and β -adrenergic and muscarinic ACh receptors.

Product References

RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist. - RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist.

Bonhaus DW, Weinhardt KK, Taylor M, DeSouza A, McNeeley PM, Szczepanski K, Fontana DJ, Trinh J, Rocha CL, Dawson MW, Flippin LA, Eglen RM. Neuropharmacology. 1997 Apr-May;36(4-5):621-9.

Absorption and brain penetration of a high affinity, highly selective 5-HT2C - Absorption and brain penetration of a high affinity, highly selective 5-HT2C

Bonhaus DW, Rocha CL, Dawson MW, Eglen RM. Ann N Y Acad Sci. 1998 Dec 15;861:269.