| Name | RS 102895 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1050 |
| Prices | $139.00, $579.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 1173022-16-6 |
| Chemical Name | 1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-onehydrochloride |
| Formula | C21H21F3N2O2.HCl |
| Molecular Weight | 426.86 |
| Purity | >99 % |
| Description | CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors. |
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Clark RD, Caroon JM, Kluge AF, Repke DB, Roszkowski AP, Strosberg AM, Baker S, Bitter SM, Okada MD. J Med Chem. 1983 May;26(5):657-61.
Mirzadegan T, Diehl F, Ebi B, Bhakta S, Polsky I, McCarley D, Mulkins M, Weatherhead GS, Lapierre JM, Dankwardt J, Morgans D Jr, Wilhelm R, Jarnagin K. J Biol Chem. 2000 Aug 18;275(33):25562-71.