RS 127445 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2089
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 199864-86-3
• Chemical Name: 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinaminehydrochloride
• Formula: C17H16FN3.HCl
• Molecular Weight: 317.79
• Purity: >98 %
• Description: High affinity 5-HT 2B receptor antagonist (pK i = 9.5). Displays 1000-fold selectivity for 5-HT 2B with good bioavailability.

Product References

RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor - RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor

Bonhaus DW, Flippin LA, Greenhouse RJ, Jaime S, Rocha C, Dawson M, Van Natta K, Chang LK, Pulido-Rios T, Webber A, Leung E, Eglen RM, Martin GR. Br J Pharmacol. 1999 Jul;127(5):1075-82.

Evidence for a control of plasma serotonin levels by 5-hydroxytryptamine(2B) - Evidence for a control of plasma serotonin levels by 5-hydroxytryptamine(2B)

Callebert J, Esteve JM, Herve P, Peoc'h K, Tournois C, Drouet L, Launay JM, Maroteaux L. J Pharmacol Exp Ther. 2006 May;317(2):724-31. Epub 2006 Feb 3.