RS 17053 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1015
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 169505-93-5
• Chemical Name: (N-[2-(2-Cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine)hydrochloride
• Formula: C24H29N2O2Cl.HCl
• Molecular Weight: 449.42
• Description: α 1A -adrenoceptor antagonist, with very high affinity for α 1A receptors (pK i and pA 2 estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α 1B and α 1D subtypes (pK i and pA 2 estimates 7.7 - 7.8).

Product References

RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, - RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha,

Ford AP, Arredondo NF, Blue DR Jr, Bonhaus DW, Jasper J, Kava MS, Lesnick J, Pfister JR, Shieh IA, Vimont RL, Williams TJ, McNeal JE, Stamey TA, Clarke DE. Mol Pharmacol. 1996 Feb;49(2):209-15.

Different subtypes of alpha 1A-adrenoceptor mediating contraction of rat - Different subtypes of alpha 1A-adrenoceptor mediating contraction of rat

Marshall I, Burt RP, Green GM, Hussain MB, Chapple CR. Br J Pharmacol. 1996 Sep;119(2):407-15.