RS 25344 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0728
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 152815-28-6
• Chemical Name: 1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)-pyrido[2,3-d]pyrimidine-2,3-(1H,3H)-dionehydrochloride
• Formula: C19H13N5O4.HCl
• Molecular Weight: 411.8
• Purity: >98 %
• Description: Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC 50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro .

Product References

Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, - Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase,

Alvarez R, Sette C, Yang D, Eglen RM, Wilhelm R, Shelton ER, Conti M. Mol Pharmacol. 1995 Oct;48(4):616-22.

Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. - Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils.

Kaneko T, Alvarez R, Ueki IF, Nadel JA. Cell Signal. 1995 Jul;7(5):527-34.

AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa. - AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa.

Bajpai M, Fiedler SE, Huang Z, Vijayaraghavan S, Olson GE, Livera G, Conti M, Carr DW. Biol Reprod. 2006 Jan;74(1):109-18. Epub 2005 Sep 21.