| Name | RS 39604 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3315 |
| Prices | $159.00, $665.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 167710-87-4 |
| Chemical Name | 1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]ethyl]piperidin-4-yl]propan-1-onehydrochloride |
| Formula | C26H36ClN3O6S.HCl |
| Molecular Weight | 590.56 |
| Purity | >99 % |
| Description | A potent and selective 5-HT 4 antagonist, with a pK i of 9.1 at 5-HT 4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT 1A, 2C, 3 and D 1 , D 2 , M 1 , M 2 , AT 1, B 1 and α 1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies. |
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Eglen RM, Wong EH, Dumuis A, Bockaert J. Trends Pharmacol Sci. 1995 Nov;16(11):391-8.
Hegde SS, Bonhaus DW, Johnson LG, Leung E, Clark RD, Eglen RM. Br J Pharmacol. 1995 Jul;115(6):1087-95.