RS 504393

• Supplier: Tocris Bioscience
• Catalog: 0889
• Prices: $199.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 300816-15-3
• Chemical Name: 6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
• Formula: C25H27N3O3
• Molecular Weight: 417.5
• Purity: >99 %
• Description: Extremely selective CCR2 chemokine receptor antagonist (IC 50 values are 98 nM and > 100 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC 50 = 330 nM) and ischemia-reperfusion injury in kidneys.

Product References

Identification of the binding site for a novel class of CCR2b chemokine receptor - Identification of the binding site for a novel class of CCR2b chemokine receptor

Mirzadegan T, Diehl F, Ebi B, Bhakta S, Polsky I, McCarley D, Mulkins M, Weatherhead GS, Lapierre JM, Dankwardt J, Morgans D Jr, Wilhelm R, Jarnagin K. J Biol Chem. 2000 Aug 18;275(33):25562-71.

CCR2 signaling contributes to ischemia-reperfusion injury in kidney. - CCR2 signaling contributes to ischemia-reperfusion injury in kidney.

Furuichi K, Wada T, Iwata Y, Kitagawa K, Kobayashi K, Hashimoto H, Ishiwata Y, Asano M, Wang H, Matsushima K, Takeya M, Kuziel WA, Mukaida N, Yokoyama H. J Am Soc Nephrol. 2003 Oct;14(10):2503-15.

Blockade of CCR2 ameliorates progressive fibrosis in kidney. - Blockade of CCR2 ameliorates progressive fibrosis in kidney.

Kitagawa K, Wada T, Furuichi K, Hashimoto H, Ishiwata Y, Asano M, Takeya M, Kuziel WA, Matsushima K, Mukaida N, Yokoyama H. Am J Pathol. 2004 Jul;165(1):237-46.