RS 67333 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0988
• Prices: $139.00, $579.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 168986-60-5
• Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanonehydrochloride
• Formula: C19H29ClN2O2.HCl
• Molecular Weight: 389.36
• Purity: >99 %
• Description: A potent and highly selective 5-HT 4 partial agonist, with pK i values of 8.7 at 5-HT 4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT 1A , 1D , 2A , 2C , D 1 , D 2 and M 1-3 . Active in vivo , with an intrinsic activity relative to 5-HT of 0.5.

Product References

Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, - Pharmacological characterization of two novel and potent 5-HT4 receptor agonists,

Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD. Br J Pharmacol. 1995 Aug;115(8):1387-92.

Central 5-HT4 receptors. - Central 5-HT4 receptors.

Eglen RM, Wong EH, Dumuis A, Bockaert J. Trends Pharmacol Sci. 1995 Nov;16(11):391-8.

The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in - The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in

Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM. Neuropharmacology. 1997 Apr-May;36(4-5):689-96.