RS 79948 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0990
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 186002-54-0
• Chemical Name: (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridinehydrochloride
• Formula: C19H28N2O3S.HCl
• Molecular Weight: 400.96
• Purity: >99 %
• Description: α 2 -adrenoreceptor antagonist (K d values are; 0.18, 0.19 and 0.42 nM for α 2B α 2C and α 2A , respectively in rat).

Product References

(8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro- - (8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-

Clark RD, Repke DB, Kilpatrick AT, Brown CM, MacKinnon AC, Clague RU, Spedding M. J Med Chem. 1989 Sep;32(9):2034-6.

Evaluation in rat of RS-79948-197 as a potential PET ligand for central alpha - Evaluation in rat of RS-79948-197 as a potential PET ligand for central alpha

Hume SP, Ashworth S, Lammertsma AA, Opacka-Juffry J, Law MP, McCarron JA, Clark RD, Nutt DJ, Pike VW. Eur J Pharmacol. 1996 Dec 12;317(1):67-73.

[3H]RS79948-197 binding to human, rat, guinea pig and pig alpha2A-, alpha2B- and - [3H]RS79948-197 binding to human, rat, guinea pig and pig alpha2A-, alpha2B- and

Uhlen S, Dambrova M, Nasman J, Schioth HB, Gu Y, Wikberg-Matsson A, Wikberg JE. Eur J Pharmacol. 1998 Feb 5;343(1):93-101.