RSVA 405

• Supplier: Tocris Bioscience
• Catalog: 0987
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 140405-36-3
• Chemical Name: 2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylicacid
• Formula: C17H20N4O2
• Molecular Weight: 312.37
• Purity: >98 %
• Description: AMP-activated protein kinase (AMPK) activator (EC 50 = 1 μ M); activates AMPK indirectly through a CaMKK β -dependent mechanism. Also inhibits LPS-induced STAT3 phosphorylation (IC 50 = 0.5 μ M). Induces autophagy and promotes A β degradation in vitro . Also inhibits adipogenesis in vitro and reduces weight gain in diet-induced obese mice.

Product References

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and - Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and

Vingtdeux V, Chandakkar P, Zhao H, d'Abramo C, Davies P, Marambaud P. FASEB J. 2011 Jan;25(1):219-31.

Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and - Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and

Vingtdeux V, Chandakkar P, Zhao H, Davies P, Marambaud P. Mol Med. 2011 Sep-Oct;17(9-10):1022-30.

Identification of potent small-molecule inhibitors of STAT3 with - Identification of potent small-molecule inhibitors of STAT3 with

Capiralla H, Vingtdeux V, Venkatesh J, Dreses-Werringloer U, Zhao H, Davies P, Marambaud P. FEBS J. 2012 Oct;279(20):3791-9.