RU 28318, potassium salt

• Supplier: Tocris Bioscience
• Catalog: 2970
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 76676-34-1
• Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylicacid,potassiumsalt
• Formula: C25H37O4K
• Molecular Weight: 440.66
• Purity: >98 %
• Description: Potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo .

Product References

The effect of the antimineralocorticoid RU 28318 on aldosterone biosynthesis in - The effect of the antimineralocorticoid RU 28318 on aldosterone biosynthesis in

Perroteau I, Netchitailo P, Delarue C, Leboulenger F, Philibert D, Deraedt R, Vaudry H. J Steroid Biochem. 1984 Apr;20(4A):853-6.

Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and - Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and

Kim PJ, Cole MA, Kalman BA, Spencer RL. J Steroid Biochem Mol Biol. 1998 Nov;67(3):213-22.

Cardiovascular and renal effects of central administration of a mineralocorticoid - Cardiovascular and renal effects of central administration of a mineralocorticoid

Rahmouni K, Barthelmebs M, Grima M, Imbs JL, De Jong W. Eur J Pharmacol. 1999 Dec 3;385(2-3):199-202.