RU-SKI 43 hydrochloride

Name RU-SKI 43 hydrochloride
Supplier Tocris Bioscience
Catalog 3828
Prices $179.00, $745.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Chemical Name 2-((2-Methylbutyl)amino)-1-(4-((3-methylphenoxy)methyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanonehydrochloride
Formula C22H30N2O2S.HCl
Molecular Weight 423.01
Purity >98 %
Description Hedgehog acyltransferase (Hhat) inhibitor (IC 50 = 850 nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro . Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable.
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Product References

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. - Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.

Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD. Nat Chem Biol. 2013 Apr;9(4):247-9.

Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. - Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma.

Petrova E, Matevossian A, Resh MD. Oncogene. 2015 Jan 8;34(2):263-8.