RWJ 56110

• Supplier: Tocris Bioscience
• Catalog: 3935
• Prices: $175.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 252889-88-6
• Chemical Name: (αS)-N-[(1S)-3-Amino-1-[[(phenylmethyl)amino]carbonyl]propyl]-α-[[[[1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indol-6-yl]amino]carbonyl]amino]-3,4-difluoro-benzenepropanamide
• Formula: C41H43Cl2F2N7O3.2HCl
• Molecular Weight: 863.65
• Purity: >96 %
• Description: Selective protease-activated receptor-1 (PAR 1 ) antagonist; displays no activity at PAR 2 , PAR 3 , or PAR 4 subtypes. Blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Also inhibits angiogenesis in a chick embryo angiogenesis model in vivo .

Product References

Design, synthesis, and biological characterization of a peptide-mimetic - Design, synthesis, and biological characterization of a peptide-mimetic

Andrade-Gordon P, Maryanoff BE, Derian CK, Zhang HC, Addo MF, Darrow AL, Eckardt AJ, Hoekstra WJ, McComsey DF, Oksenberg D, Reynolds EE, Santulli RJ, Scarborough RM, Smith CE, White KB. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12257-62.

Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, - Discovery of potent peptide-mimetic antagonists for the human thrombin receptor,

Maryanoff BE, Zhang HC, Andrade-Gordon P, Derian CK. Curr Med Chem Cardiovasc Hematol Agents. 2003 Mar;1(1):13-36.

Blockade of angiogenesis by small molecule antagonists to protease-activated - Blockade of angiogenesis by small molecule antagonists to protease-activated

Zania P, Kritikou S, Flordellis CS, Maragoudakis ME, Tsopanoglou NE. J Pharmacol Exp Ther. 2006 Jul;318(1):246-54. Epub 2006 Apr 4.