Ac-RYYRIK-NH 2

Name Ac-RYYRIK-NH 2
Supplier Tocris Bioscience
Catalog 2609
Prices $189.00
Sizes 1 mg
Cas Number 200959-48-4
Formula C44H70N14O9
Molecular Weight 939.12
Description High affinity ligand for the NOP site (K i = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo , inhibiting locomotor activity in mice.
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Product References

Binding and in vitro activities of peptides with high affinity for the - Binding and in vitro activities of peptides with high affinity for the

Dooley CT, Spaeth CG, Berzetei-Gurske IP, Craymer K, Adapa ID, Brandt SR, Houghten RA, Toll L. J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.

Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations - Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations

Berger H, Albrecht E, Wallukat G, Bienert M. Br J Pharmacol. 1999 Feb;126(3):555-8.

The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits - The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits

Berger H, Bigoni R, Albrecht E, Richter RM, Krause E, Bienert M, Calo' G. Peptides. 2000 Jul;21(7):1131-9.