| Name | S 14506 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5188 |
| Prices | $189.00, $765.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 286369-38-8 |
| Chemical Name | 4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamidehydrochloride |
| Formula | C24H26FN3O2.HCl |
| Molecular Weight | 443.94 |
| Purity | >99 % |
| Description | Highly potent selective 5-HT 1A receptor full agonist (pK i values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT 1A , 5-HT 1B , 5-HT 1C , 5-HT 2 and 5-HT 3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo . |
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Lima L, Laporte AM, Gaymard C, Spedding M, Mocaer E, Hamon M. J Neural Transm. 1997;104(10):1059-75.
Milligan G, Kellett E, Dacquet C, Dubreuil V, Jacoby E, Millan MJ, Lavielle G, Spedding M. Neuropharmacology. 2001 Mar;40(3):334-44.