S 18886

• Supplier: Tocris Bioscience
• Catalog: 1771
• Prices: $119.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 165538-40-9
• Chemical Name: (6R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoicacid
• Formula: C20H22ClNO4S
• Molecular Weight: 407.91
• Purity: >98 %
• Description: Potent thromboxane A 2 (TP) inhibitor (IC 50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro . Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.

Product References

Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as - Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as

Cimetiere B, Dubuffet T, Muller O, Descombes JJ, Simonet S, Laubie M, Verbeuren TJ, Lavielle G. Bioorg Med Chem Lett. 1998 Jun 2;8(11):1375-80.

Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. - Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists.

Wang X, Liu L, Huang L, Herbst-Robinson K, Cornec AS, James MJ, Sugiyama S, Bassetto M, Brancale A, Trojanowski JQ, Lee VM, Smith AB 3rd, Brunden KR, Ballatore C. ACS Med Chem Lett. 2014 Jul 24;5(9):1015-20.