| Name | S 32212 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3432 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 847871-78-7 |
| Chemical Name | 1,2-Dihydro-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-3H-benz[e]indole-3-carboxamidehydrochloride |
| Formula | C25H28N4O2.HCl |
| Molecular Weight | 452.98 |
| Purity | >99 % |
| Description | Inverse agonist of 5-HT 2C receptors (pK i = 8.18 at human 5-HT 2C INI receptors). Also an antagonist of human α 2 -adrenoceptors. Displays negligible affinity for α 1A -adrenoceptors, histamine H 1 receptors and muscarinic M 1 receptors. |
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Dekeyne A, Brocco M, Loiseau F, Gobert A, Rivet JM, Di Cara B, Cremers TI, Flik G, Fone KC, Watson DJ, Papp M, Sharp T, Serres F, Cespuglio R, Olivier B, Chan JS, Lavielle G, Millan MJ. J Pharmacol Exp Ther. 2012 Mar;340(3):765-80.
Millan MJ, Mannoury la Cour C, Chanrion B, Dupuis DS, Di Cara B, Audinot V, Cussac D, Newman-Tancredi A, Kamal M, Boutin JA, Jockers R, Marin P, Bockaert J, Muller O, Dekeyne A, Lavielle G. J Pharmacol Exp Ther. 2012 Mar;340(3):750-64.