S 32826

• Supplier: Tocris Bioscience
• Catalog: 4508
• Prices: $189.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 1103672-43-0
• Chemical Name: [4-(Tetradecanoylamino)benzyl]phosphonicaciddisodiumsalt
• Formula: C21H34NO4PNa2
• Molecular Weight: 441.45
• Purity: >98 %
• Description: Inhibitor of autotaxin (IC 50 = 9 nM). Displays similar inhibitory effects at all three autotaxin isoforms ( α , β and γ ). Exhibits no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 μ M. Inhibits LPA release from adipocytes (IC 50 = 90 nM).

Product References

S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications - S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications

Ferry G, Moulharat N, Pradere JP, Desos P, Try A, Genton A, Giganti A, Beucher-Gaudin M, Lonchampt M, Bertrand M, Saulnier-Blache JS, Tucker GC, Cordi A, Boutin JA. J Pharmacol Exp Ther. 2008 Dec;327(3):809-19.

Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes - Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes

Li S, Wang B, Xu Y, Zhang J. Mol Cancer. 2011 Feb 12;10:18.