SA 4503 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5577
• Prices: $165.00, $685.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 165377-44-6
• Chemical Name: 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazinedihydrochloride
• Formula: C23H32N2O2.2HCl
• Molecular Weight: 441.43
• Purity: >98 %
• Description: Selective σ 1 receptor agonist (IC 50 = 17.4 nM). Exhibits selectivity for σ 1 over σ 2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo . Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.

Product References

Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. - Binding properties of SA4503, a novel and selective sigma 1 receptor agonist.

Matsuno K, Nakazawa M, Okamoto K, Kawashima Y, Mita S. Eur J Pharmacol. 1996 Jun 13;306(1-3):271-9.

Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and - Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and

Lever JR, Gustafson JL, Xu R, Allmon RL, Lever SZ. Synapse. 2006 May;59(6):350-8.

The sigma-1 receptor enhances brain plasticity and functional recovery after - The sigma-1 receptor enhances brain plasticity and functional recovery after

Ruscher K, Shamloo M, Rickhag M, Ladunga I, Soriano L, Gisselsson L, Toresson H, Ruslim-Litrus L, Oksenberg D, Urfer R, Johansson BB, Nikolich K, Wieloch T. Brain. 2011 Mar;134(Pt 3):732-46.

Stimulation of sigma1-receptor restores abnormal mitochondrial Ca(2)(+) - Stimulation of sigma1-receptor restores abnormal mitochondrial Ca(2)(+)

Tagashira H, Zhang C, Lu YM, Hasegawa H, Kanai H, Han F, Fukunaga K. Biochim Biophys Acta. 2013 Apr;1830(4):3082-94. doi: