Sal 003

• Supplier: Tocris Bioscience
• Catalog: 4652
• Prices: $165.00, $685.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1164470-53-4
• Chemical Name: 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
• Formula: C18H15Cl4N3OS
• Molecular Weight: 463.21
• Purity: >99 %
• Description: Cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2 α ). Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.

Product References

The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote - The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote

Baltzis D, Pluquet O, Papadakis AI, Kazemi S, Qu LK, Koromilas AE. J Biol Chem. 2007 Oct 26;282(43):31675-87. Epub 2007 Sep 4.

eIF2alpha phosphorylation bidirectionally regulates the switch from short- to - eIF2alpha phosphorylation bidirectionally regulates the switch from short- to

Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjevic K, Lacaille JC, Nader K, Sonenberg N. Cell. 2007 Apr 6;129(1):195-206.

PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent - PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent

Raven JF, Baltzis D, Wang S, Mounir Z, Papadakis AI, Gao HQ, Koromilas AE. J Biol Chem. 2008 Feb 8;283(6):3097-108. Epub 2007 Dec 6.