Salermide

• Supplier: Tocris Bioscience
• Catalog: 0634
• Prices: $109.00, $459.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1105698-15-4
• Chemical Name: N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide
• Formula: C26H22N2O2
• Molecular Weight: 394.47
• Purity: >98 %
• Description: SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro . Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours.

Product References

Design, synthesis, and biological evaluation of sirtinol analogues as class III - Design, synthesis, and biological evaluation of sirtinol analogues as class III

Mai A, Massa S, Lavu S, Pezzi R, Simeoni S, Ragno R, Mariotti FR, Chiani F, Camilloni G, Sinclair DA. J Med Chem. 2005 Dec 1;48(24):7789-95.

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. - Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Imhof A, Mato JM, Esteller M, Fraga MF. Oncogene. 2009 Feb 12;28(6):781-91.

Characterization of sirtuin inhibitors in nematodes expressing a muscular - Characterization of sirtuin inhibitors in nematodes expressing a muscular

Pasco MY, Rotili D, Altucci L, Farina F, Rouleau GA, Mai A, Neri C. J Med Chem. 2010 Feb 11;53(3):1407-11.