Salirasib

Name Salirasib
Supplier Tocris Bioscience
Catalog 4127
Prices $75.00, $315.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 162520-00-5
Chemical Name 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoicacid
Formula C22H30O2S
Molecular Weight 358.54
Purity >98 %
Description Inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.
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Product References

Dislodgment and accelerated degradation of Ras. - Dislodgment and accelerated degradation of Ras.

Haklai R, Weisz MG, Elad G, Paz A, Marciano D, Egozi Y, Ben-Baruch G, Kloog Y. Biochemistry. 1998 Feb 3;37(5):1306-14.

Growth of poorly differentiated endometrial carcinoma is inhibited by combined - Growth of poorly differentiated endometrial carcinoma is inhibited by combined

Faigenbaum R, Haklai R, Ben-Baruch G, Kloog Y. Oncotarget. 2013 Feb;4(2):316-28.

Ras inhibition enhances autophagy, which partially protects cells from death. - Ras inhibition enhances autophagy, which partially protects cells from death.

Schmukler E, Grinboim E, Schokoroy S, Amir A, Wolfson E, Kloog Y, Pinkas-Kramarski R. Oncotarget. 2013 Jan;4(1):145-55.