Salubrinal

• Supplier: Tocris Bioscience
• Catalog: 0636
• Prices: $189.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 405060-95-9
• Chemical Name: 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
• Formula: C21H17N4OSCl3
• Molecular Weight: 479.81
• Purity: >99 %
• Description: Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2 α ). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC 50 ~ 15 μ M).

Product References

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER - A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER

Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. Science. 2005 Feb 11;307(5711):935-9.

Structure-activity relationship studies of salubrinal lead to its active - Structure-activity relationship studies of salubrinal lead to its active

Long K, Boyce M, Lin H, Yuan J, Ma D. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3849-52.