Sanguinarine chloride

Name Sanguinarine chloride
Supplier Tocris Bioscience
Catalog 1344
Prices $149.00, $629.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 5578-73-4
Chemical Name 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridiniumchloride
Formula C20H14ClNO4
Molecular Weight 367.78
Purity >97 %
Description Inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro . Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC 50 = 10 μ M). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G 1 phase; inhibits cell growth in human prostate carcinoma cells.
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Product References

The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active - The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active

Vogt A, Tamewitz A, Skoko J, Sikorski RP, Giuliano KA, Lazo JS. J Biol Chem. 2005 May 13;280(19):19078-86. Epub 2005 Mar 7.

Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in - Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in

Aburai N, Yoshida M, Ohnishi M, Kimura K. Biosci Biotechnol Biochem. 2010;74(3):548-52. Epub 2010 Mar 7.