Saquinavir mesylate

• Supplier: Tocris Bioscience
• Catalog: 3617
• Prices: $79.00, $335.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 149845-06-7
• Chemical Name: (2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamidemethanesulfonate
• Formula: C38H50N6O5.CH4O3S
• Molecular Weight: 766.95
• Purity: >99 %
• Description: Inhibitor of human immunodeficiency virus (HIV) protease (K i values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity.

Product References

Rational design of peptide-based HIV proteinase inhibitors. - Rational design of peptide-based HIV proteinase inhibitors.

Roberts NA, Martin JA, Kinchington D, Broadhurst AV, Craig JC, Duncan IB, Galpin SA, Handa BK, Kay J, Krohn A, et al.. Science. 1990 Apr 20;248(4953):358-61.

Specific inhibitor of human immunodeficiency virus proteinase prevents the - Specific inhibitor of human immunodeficiency virus proteinase prevents the

Krausslich HG. J Virol. 1992 Jan;66(1):567-72.

A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary - A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary

Tucker TJ, Lumma WC Jr, Payne LS, Wai JM, de Solms SJ, Giuliani EA, Darke PL, Heimbach JC, Zugay JA, Schleif WA, et al.. J Med Chem. 1992 Jul 10;35(14):2525-33.