Sarpogrelate hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2975
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 135159-51-2
• Chemical Name: Succinicacidmono-(1-dimethylaminomethyl-2-(2-[2-(3-methoxyphenyl)ethyl]phenoxy)ethyl)esterhydrochloride
• Formula: C24H31NO6.HCl
• Molecular Weight: 465.97
• Purity: >99 %
• Description: Selective 5-HT 2A receptor antagonist (pK i values are 8.52, 7.43 and 6.57 for 5-HT 2A , 5-HT 2C and 5-HT 2B receptors respectively). Displays selectivity over 5-HT 1 , 5-HT 3 , 5-HT 4 H 1 , H 2 , M 3 , α 1 -adrenergic, α 2 -adrenergic and β -adrenergic receptors. Displays cardioprotective activity in vivo .

Product References

Blockade of 5-HT(2A) receptors by sarpogrelate protects the heart against - Blockade of 5-HT(2A) receptors by sarpogrelate protects the heart against

Brasil D, Temsah RM, Kumar K, Kumamoto H, Takeda N, Dhalla NS. J Cardiovasc Pharmacol Ther. 2002 Jan;7(1):53-9.

Identification of the binding sites and selectivity of sarpogrelate, a novel - Identification of the binding sites and selectivity of sarpogrelate, a novel

Rashid M, Manivet P, Nishio H, Pratuangdejkul J, Rajab M, Ishiguro M, Launay JM, Nagatomo T. Life Sci. 2003 May 30;73(2):193-207.

Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine - Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine

Nishiyama T. Eur J Pharmacol. 2009 Jul 1;614(1-3):122-7.